Brans J W, Lindeboom R, Aramideh M, Speelman J D
Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands.
Neurology. 1998 May;50(5):1461-3. doi: 10.1212/wnl.50.5.1461.
We investigated the long-term effect of botulinum toxin type A (BTA) on impairment as well as functional health in terms of disability, handicap, and quality of life in 64 patients with cervical dystonia. These patients, who first participated in a double-blind trial, were followed for another 12 months. Fifty-four patients continued treatment after 12 months of follow-up and showed improvement on all scales. Furthermore, this effectiveness appeared to increase during follow-up, which suggests a cumulative clinical effect of BTA.
我们研究了A型肉毒毒素（BTA）对64例颈部肌张力障碍患者的功能损害以及残疾、残障和生活质量方面的功能健康的长期影响。这些患者最初参与了一项双盲试验，并随访了另外12个月。54例患者在随访12个月后继续接受治疗，且在所有量表上均有改善。此外，这种有效性在随访期间似乎有所增加，这表明BTA具有累积临床效应。
