Stewart R D, Hake C L, Wu A
Scand J Work Environ Health. 1976 Jun;2(2):57-70. doi: 10.5271/sjweh.2817.
Twenty male and female subjects were exposed repetitively to methylene chloride (CH2Cl2) vapor, 50, 100, 250, and 500 ppm, for 1,3, or 7.5 h in a controlled-environment chamber. Postexposure alveolar breath samples were collected in small glass breath tubes and analyzed for CH2Cl2 by gas chromatography. From these data is a series of breath CH2Cl2 excretion curves were constructed that can be used to estimate the magnitude of a recent exposure. The CH2CL2 breath concentration in the immediate postexposure period accurately reflected the vapor concentration to which the subjects had been exposed most recently. Breath samples collected 1--2 h following exposure were accurate indicators of the time-weighted average vapor exposure experienced by the subjects during the previous 8 h of occupational exposure. Breath analysis offers a practical, noninvasive method for monitoring occupational exposure to CH2Cl2.
二十名男性和女性受试者在可控环境舱中反复暴露于浓度为50、100、250和500 ppm的二氯甲烷（CH2Cl2）蒸气中，暴露时间分别为1小时、3小时或7.5小时。暴露后，在小型玻璃呼吸管中收集肺泡呼吸样本，并通过气相色谱法分析其中的二氯甲烷。根据这些数据构建了一系列呼出二氯甲烷排泄曲线，可用于估算近期暴露的程度。暴露后即刻呼出的二氯甲烷浓度准确反映了受试者最近接触的蒸气浓度。暴露后1至2小时收集的呼吸样本是受试者在之前8小时职业暴露期间经历的时间加权平均蒸气暴露的准确指标。呼吸分析为监测职业性二氯甲烷暴露提供了一种实用的非侵入性方法。
