Andrade M A, Sander C, Valencia A
Protein Design Group, CNB-CSIC, Campus Universidad Autonoma, Cantoblanco, Madrid, Spain.
FEBS Lett. 1998 Apr 10;426(1):7-16. doi: 10.1016/s0014-5793(98)00277-4.
The recent availability of the full Saccharomyces cerevisiae genome offers a perfect opportunity for revising the number of homologues to human disease-related proteins. We carried out automatic analysis of the complete S. cerevisiae genome and of the set of human disease-related proteins as identified in the SwissProt sequence data base. We identified 285 yeast proteins similar to 155 human disease-related proteins, including 239 possible cases of human-yeast direct functional equivalence (orthology). Of these, 40 cases are suggested as new, previously undiscovered relationships. Four of them are particularly interesting, since the yeast sequence is the most phylogenetically distant member of the protein family, including proteins related to diseases such as phenylketonuria, lupus erythematosus, Norum and fish eye disease and Wiskott-Aldrich syndrome.
酿酒酵母全基因组的近期可得性为修正与人类疾病相关蛋白质的同源物数量提供了绝佳机会。我们对完整的酿酒酵母基因组以及在瑞士蛋白质数据库中鉴定出的人类疾病相关蛋白质组进行了自动分析。我们鉴定出285种酵母蛋白质与155种人类疾病相关蛋白质相似，其中包括239种可能存在人类-酵母直接功能等效（直系同源）的情况。其中，40种情况被认为是新的、先前未被发现的关系。其中四种情况特别有趣，因为酵母序列是该蛋白质家族中系统发育关系最远的成员，包括与苯丙酮尿症、红斑狼疮、诺鲁姆病和鱼眼病以及威斯科特-奥尔德里奇综合征等疾病相关的蛋白质。
