Juriloff D M, Trasler D G
Teratology. 1976 Aug;14(1):35-41. doi: 10.1002/tera.1420140106.
It was proposed that embryonic face shape is one of the quantitative variables underlying the threshold trait, cleft lip. To test the hypothesis several facial dimensions were measured in photographs of embryos at an early stage of formation of the face in 3 lines of mice. The lines had been selected from one original population using frequency of cleft lip induced by 6-aminonicotinamide as the selection criterion. Line L was susceptible to spontaneous cleft lip; lines M and C were not. Line L had a significantly smaller distance between the nasal pits than the other 2 lines, but did not differ in overall head size. A trend towards reduced angle between the medial nasal processes in the L line was noted, though this was not statistically significant. These results were predicted by the face-shape hypothesis.
有人提出胚胎面部形状是阈值性状唇裂潜在的定量变量之一。为了验证这一假设，在3组小鼠面部形成早期阶段的胚胎照片中测量了几个面部维度。这些组是从一个原始种群中选择出来的，使用6-氨基烟酰胺诱导的唇裂频率作为选择标准。L组易患自发性唇裂；M组和C组则不易患。L组鼻凹之间的距离明显小于其他两组，但总体头部大小没有差异。虽然L组内侧鼻突之间的角度有减小的趋势，但这在统计学上并不显著。这些结果是由面部形状假说预测出来的。
