哺乳动物肺中一种新型的转化生长因子β2反义转录物。
A novel transforming growth factor beta2 antisense transcript in mammalian lung.
作者信息
Coker R K, Laurent G J, Dabbagh K, Dawson J, McAnulty R J
机构信息
Centre for Cardiopulmonary Biochemistry and Respiratory Medicine, University College London Medical School, Rayne Institute, 5 University Street, London WC1E 6JJ, UK.
出版信息
Biochem J. 1998 Jun 1;332 ( Pt 2)(Pt 2):297-301. doi: 10.1042/bj3320297.
Abstract
Transforming growth factor (TGF) beta2 gene expression was examined in murine, rat and human lung by in situ hybridization with riboprobes. Hybridization signal was observed in a variety of cells with the sense probe, and Northern-blot analysis with this probe demonstrated the presence of a novel 3.5 kb transcript. This first report suggesting the existance of a natural TGFbeta2 antisense transcript raises the possibility that such a transcript may play a role in regulating TGFbeta2 production.
摘要
通过与核糖探针进行原位杂交，在小鼠、大鼠和人类肺组织中检测了转化生长因子（TGF）β2基因的表达。用正义探针在多种细胞中观察到杂交信号，用该探针进行的Northern印迹分析表明存在一种新的3.5 kb转录本。这篇首次报道提示存在天然TGFβ2反义转录本的文章，增加了这种转录本可能在调节TGFβ2产生中发挥作用的可能性。
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