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[肝脏神经支配紊乱时的磷酸戊糖途径酶活性]

[Pentosephosphate shunt enzymatic activity in the liver in its disordered innervation].

作者信息

Aksenova V M

出版信息

Ukr Biokhim Zh. 1976 Apr-Jun;48(3):300-2.

PMID:960238
Abstract

Partial denervation of the liver evoked the dissection of subphrenic vagus nerves and nerves of the hepatogastric duodenal ligament tissue stimulates synthesis of pentoses in the liver due to the oxidative mechanism and inhibits the process of unoxidative formation of pentoses. Three-four weeks after the operation one may observe a 72% increase in the activity of glucose-6-phosphate dehydrogenase in the liver tissue and a 29 and 21% drop in the activity of transketolase and enzymes, respectively, participating in metabolism of ribose-5-phosphate. The content of soluble proteins in the liver with deneravation is unchanged. A correlation is observed between these changes and those in the content of nucleic acids, an opinion is confirmed on the autonomous character of the oxidative and unoxidative phases of the pentose cycle.

摘要

肝脏部分去神经支配会引起膈下迷走神经的解剖,肝胃十二指肠韧带组织的神经通过氧化机制刺激肝脏中戊糖的合成,并抑制戊糖的非氧化形成过程。手术后三到四周,可观察到肝组织中葡萄糖-6-磷酸脱氢酶的活性增加72%,而参与5-磷酸核糖代谢的转酮醇酶和其他酶的活性分别下降29%和21%。去神经支配后肝脏中可溶性蛋白质的含量没有变化。观察到这些变化与核酸含量的变化之间存在相关性,这证实了关于戊糖循环氧化和非氧化阶段自主性的观点。

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