Geetha T, Varalakshmi P, Latha R M
Department of Medical Biochemistry, Dr. A.L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
Pharmacol Res. 1998 Mar;37(3):191-5. doi: 10.1006/phrs.1997.0278.
Lupeol, a pentacyclic triterpene was isolated from C. nurvala stem bark and its ester lupeol linoleate was synthesised. These triterpenes were tested for their anti-inflammatory activity in complete Freund's adjuvant induced arthritis rats. For some time free radicals have been implicated in damage to connective tissues during inflammatory conditions and arthritis. Lupeol and lupeol linoleate were administered orally at the dose level of 50 mg kg-1 body weight daily for 8 days, from the 11th to 18th day postadjuvantly. There was a significant increase in lipid peroxide level in plasma of arthritic rats but it was found to be decreased in the liver. The antioxidant enzymes superoxide dismutase, glutathione peroxidase and catalase were elevated in both the liver and haemolysate in adjuvant-induced rats. Blood glutathione was decreased in arthritis. The triterpenes reduced the above alterations produced in arthritic animals. The effect of lupeol linoleate was found to be better in this respect when compared with lupeol.
羽扇豆醇，一种五环三萜，从努尔瓦拉金合欢茎皮中分离得到，并合成了其酯类化合物亚油酸羽扇豆醇酯。在完全弗氏佐剂诱导的关节炎大鼠中测试了这些三萜的抗炎活性。一段时间以来，自由基一直被认为与炎症和关节炎期间结缔组织的损伤有关。从佐剂注射后第11天到第18天，羽扇豆醇和亚油酸羽扇豆醇酯以50毫克/千克体重的剂量每日口服给药8天。关节炎大鼠血浆中的脂质过氧化物水平显著升高，但在肝脏中发现有所降低。在佐剂诱导的大鼠中，肝脏和溶血产物中的抗氧化酶超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶均升高。关节炎时血液中的谷胱甘肽减少。三萜类化合物减轻了关节炎动物产生的上述变化。在这方面，与羽扇豆醇相比，亚油酸羽扇豆醇酯的效果更好。
