黄荆叶提取物对完全弗氏佐剂诱导的关节炎大鼠体内自由基清除剂的影响。
Effect ofVitex negundo leaf extract on the free radicals scavengers in complete Freund's adjuvant induced arthritic rats.
作者信息
Devi P Renuka, Kumari S Krishna, Kokilavani C
机构信息
Department of Biochemistry, Kovai Kalaimagal College of Arts and Science, Narasipuram, 641 109 Coimpatore, TamilNadu India.
出版信息
Indian J Clin Biochem. 2007 Mar;22(1):143-7. doi: 10.1007/BF02912899.
Abstract
The effect of the oral administration ofVitex negundo leaf extract on the levels of enzymic and non-enzymic antioxidants were studied in the adjuvant induced arthritic (AIA) rats The levels of antioxidant enzymes such as SOD, CAT, GPx, G6PD, GSH and Vit-C were estimated in various groups of the experimental rats. It was observed that the antioxidant enzyme levels in the AIA were significantly low when compared to normal rats. A significant decrease in enzymic antioxidant-SOD, CAT, GPx, G6PD and non-enzymic antioxidant-GSH, Vit-C were observed in the liver of AIA rats compared to the normal rats. These results suggest that the leaf extract ofVitex negundo possesses antioxidant activity.
摘要
研究了口服黄荆叶提取物对佐剂诱导性关节炎（AIA）大鼠体内酶促和非酶促抗氧化剂水平的影响。在不同组的实验大鼠中测定了超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、葡萄糖-6-磷酸脱氢酶（G6PD）、谷胱甘肽（GSH）和维生素C等抗氧化酶的水平。观察到与正常大鼠相比，AIA大鼠体内的抗氧化酶水平显著降低。与正常大鼠相比，在AIA大鼠的肝脏中观察到酶促抗氧化剂SOD、CAT、GPx、G6PD以及非酶促抗氧化剂GSH、维生素C显著减少。这些结果表明，黄荆叶提取物具有抗氧化活性。
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