Stargardt黄斑营养不良患者的多焦视网膜电图
Multifocal electroretinography in patients with Stargardt's macular dystrophy.
作者信息
Kretschmann U, Seeliger M W, Ruether K, Usui T, Apfelstedt-Sylla E, Zrenner E
机构信息
University Eye Hospital, Department for Pathophysiology of Vision and Neuro-Ophthalmology, Tuebingen, Germany.
出版信息
Br J Ophthalmol. 1998 Mar;82(3):267-75. doi: 10.1136/bjo.82.3.267.
AIMS
To describe the topography of multifocal electroretinograms (ERGs) and to explore its diagnostic value in patients with Stargardt's macular dystrophy (SMD).
METHODS
51 patients with SMD were examined by means of the m-sequence technique to characterise the topography of electroretinographic responses in the central visual field. The results were compared with data from 30 normal volunteers.
RESULTS
In 49 of 51 patients with SMD, macular electroretinographic activity was markedly diminished or non-detectable. Towards more peripheral areas, ERG responses of the SMD patients approached those of normals. Implicit times were not markedly delayed at any eccentricity.
CONCLUSION
In contrast with Ganzfeld electroretinography, multifocal electroretinography is useful to detect foveal dysfunction in SMD. Areas of dysfunction were found to be usually larger than expected from psychophysical measurements and morphological alteration. In early stages of the disease it was possible to detect foveal dysfunction, even in patients lacking morphological fundus changes and with good visual acuity.
目的
描述多焦视网膜电图（ERG）的地形图，并探讨其在Stargardt黄斑营养不良（SMD）患者中的诊断价值。
方法
采用m序列技术对51例SMD患者进行检查，以描绘中心视野视网膜电图反应的地形图。将结果与30名正常志愿者的数据进行比较。
结果
51例SMD患者中有49例黄斑视网膜电图活动明显减弱或无法检测到。在更周边区域，SMD患者的ERG反应接近正常者。在任何偏心度下，潜伏时间均未明显延迟。
结论
与全视野视网膜电图不同，多焦视网膜电图有助于检测SMD中的黄斑功能障碍。发现功能障碍区域通常比心理物理学测量和形态学改变所预期的更大。在疾病早期，即使在眼底缺乏形态学改变且视力良好的患者中，也有可能检测到黄斑功能障碍。
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