Byer N E
Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 May-Jun;81(3 Pt 1):458-71.
The natural history of senile retionoschisis was studied by observing a series of 193 eyes of 108 nonreferred patients who had no history of significant ocular disease, while refraining from the use of any form of prophylactic intervention, for follow-up periods ranging from 2 to 11 years. One patient at the outset of the study had double layer holes, which had already led to a localized subclinical retinal detachment that had been left untreated, and did not progress during observation for more than two years. One patient developed a small asymptomatic nonprogressive retinal detachment from an outer layer hole. Four eyes showed posterior extension, but in only one was this serious. Nine eyes developed new retinal breaks, one in both layers, but none progressed in extent of retinoschisis or to retinal detachment. Of particular interest were seven eyes which showed unmistakable regression, the retinoschisis disappearing completely in six eyes. Based on reported cases, an estimated computation is made which places the probable risk of frank, progressive, symptomatic retinal detachment resulting from retinoschisis at about 0.07%. Four indications for treatment are given which are considered justified at the present state of our knowledge.
通过观察108例无严重眼部疾病史的非转诊患者的193只眼，在不进行任何形式预防性干预的情况下，随访2至11年，研究了老年性视网膜劈裂的自然病程。研究开始时，有1例患者存在双层裂孔，已导致局限性亚临床视网膜脱离，未予治疗，在两年多的观察期内未进展。1例患者因外层裂孔发展为小的无症状性非进展性视网膜脱离。4只眼出现后极部扩展，但仅1只眼情况严重。9只眼出现新的视网膜裂孔，其中1只眼两层均有裂孔，但视网膜劈裂范围均未进展，也未发展为视网膜脱离。特别值得关注的是7只眼出现了明显的退缩，其中6只眼的视网膜劈裂完全消失。根据报告的病例进行了估计计算，结果显示视网膜劈裂导致明显、进行性、有症状性视网膜脱离的可能风险约为0.07%。给出了4条治疗指征，就我们目前的知识水平而言，这些指征被认为是合理的。
