Fournier P E, Rizzoli R, Slosman D O, Theintz G, Bonjour J P
Department of Internal Medicine, University Hospital, Geneva, Switzerland.
Osteoporos Int. 1997;7(6):525-32. doi: 10.1007/BF02652557.
During puberty, the marked increased in both standing height and bone mass appear to be dissociated in time, the former occurring earlier than the latter. However, the age or pubertal stage at which this dissociation is maximal in girls as opposed to boys, and whether this dissociation is similar at all parts of the skeleton, are not clearly established. Standing height and bone mineral mass, as assessed by measuring areal bone mineral density (BMD), at the levels of the lumbar spine, femoral neck and midfemoral shaft, were measured in 98 females and 100 males between the ages of 9 and 19 years twice at a 1-year interval. In males, the greatest difference between height and BMD gains occurred in the 13-14 year age group and was more pronounced for the lumbar spine and femoral neck than for the midfemoral shaft. In females, the greatest difference was detectable at a younger age (11-12 year age group) and appeared to be of a lower magnitude than in males. In both genders, the maximal difference occurred during the period of peak height velocity, which corresponded to the pubertal stages P2-P3. Such a dissociation between the rates of statural growth and mineral mass accrual could define a state of relatively low bone mass and contribute to the higher incidence of fracture known to occur at the age and/or pubertal stage when this dissociation is maximal.
在青春期，身高和骨量的显著增加在时间上似乎是分离的，身高增长比骨量增长更早出现。然而，与男孩相比，女孩身高和骨量增长分离最大时的年龄或青春期阶段，以及这种分离在骨骼各部位是否相似，目前尚不清楚。对98名9至19岁的女性和100名9至19岁的男性，每隔1年测量两次腰椎、股骨颈和股骨干中部的身高及通过测量面积骨密度（BMD）评估的骨矿物质含量。在男性中，身高和骨量增加之间的最大差异出现在13 - 14岁年龄组，且在腰椎和股骨颈比在股骨干中部更为明显。在女性中，最大差异在较年轻的年龄（11 - 12岁年龄组）即可检测到，且似乎比男性的差异程度更低。在两性中，最大差异都出现在身高增长速度峰值期，这与青春期阶段P2 - P3相对应。身高增长速度和矿物质积累速度之间的这种分离可能会导致骨量相对较低的状态，并导致在这种分离最大的年龄和/或青春期阶段已知的骨折发生率较高。
