Wang M C, Luz Villa M, Marcus R, Kelsey J L
Department of Health Research and Policy, Stanford University School of Medicine, California 94305-5092, USA.
Osteoporos Int. 1997;7(6):533-8. doi: 10.1007/BF02652558.
We investigated the associations of vitamin C, calcium and protein intakes with bone mass at the femoral neck and lumbar spine in postmenopausal Mexican American women. Bone mass was measured by dual-energy X-ray absorptiometry (DXA) and expressed as areal (BMD, g/cm2) and volumetric (bone mineral apparent density or BMAD, g/cm3) bone mineral density. Diet was assessed using a modified version of the National Cancer Institute Food Questionnaire, which was administered by trained bilingual interviewers familiar with Mexican dietary practices. Data gathered from 125 subjects were analyzed using multiple linear regression analysis with age, body mass index (BMI), acculturation, years of estrogen use, physical activity, total energy intake, and the nutrient of interest as independent variables. Neither calcium nor calcium/protein ratio was associated with bone mineral density. There was evidence of a positive association between dietary vitamin C intake and femoral neck BMD (beta = 0.0002 g/cm2 per mg/day, SE = 0.00006, p < 0.05), but vitamin C was not associated with lumbar spine bone mass. Further investigation of the role of vitamin C in skeletal health is warranted.
我们研究了绝经后墨西哥裔美国女性维生素C、钙和蛋白质摄入量与股骨颈及腰椎骨量之间的关联。骨量通过双能X线吸收法（DXA）测量，并以面积骨密度（BMD，g/cm²）和体积骨密度（骨矿物质表观密度或BMAD，g/cm³）表示。饮食情况通过美国国立癌症研究所食物问卷的修订版进行评估，该问卷由熟悉墨西哥饮食习惯的训练有素的双语访谈员进行发放。对从125名受试者收集的数据进行多元线性回归分析，将年龄、体重指数（BMI）、文化适应程度、雌激素使用年限、身体活动、总能量摄入以及感兴趣的营养素作为自变量。钙和钙/蛋白质比值均与骨密度无关。有证据表明饮食中维生素C摄入量与股骨颈骨密度呈正相关（β = 0.0002 g/cm² 每毫克/天，标准误 = 0.00006，p < 0.05），但维生素C与腰椎骨量无关。有必要进一步研究维生素C在骨骼健康中的作用。
