Bahramali H, Gordon E, Li W M, Rennie C, Wright J
Department of Psychological Medicine, Westmead Hospital, NSW, Australia.
Int J Neurosci. 1998 Feb;93(1-2):75-85. doi: 10.3109/00207459808986414.
A number of studies have examined the average late component Event Related Potential (ERP) and Reaction Time (RT) in response to multiple target stimuli (across-trial averages). This study demonstrates within-trial differences in ERP brain function associated with relatively fast and slow RTs in 50 normal subjects. A conventional auditory oddball paradigm (with a 1 ISI) was employed. Increased ERP N100 and N200 amplitude (and decreased P200 amplitude), as well as earlier P200, N200 and P300 latency were found in the fast compared with the slow ERP subaverages. These results show the potential to elucidate temporal and spatial dynamics of brain function associated with changes in performance, in conventional "cognitive" paradigms applicable to both health and disease states.
许多研究已经考察了对多个目标刺激的平均晚期成分事件相关电位（ERP）和反应时间（RT）（跨试验平均值）。本研究证明了50名正常受试者中，ERP脑功能在试验内与相对较快和较慢RT相关的差异。采用了传统的听觉Oddball范式（间隔1个刺激间隔时间）。与慢ERP子平均值相比，快ERP子平均值中ERP的N100和N200波幅增加（P200波幅降低），以及P200、N200和P300潜伏期提前。这些结果表明，在适用于健康和疾病状态的传统“认知”范式中，有潜力阐明与表现变化相关的脑功能的时间和空间动态。
