Bahramali H, Gordon E, Li W M, Rennie C, Wright J, Meares R
Department of Psychological Medicine, Westmead Hospital, NSW, f2p4ralia.
Int J Neurosci. 1998 Sep;95(3-4):155-65. doi: 10.3109/00207459809003337.
A number of studies have examined across-trial averaged late component. Event Related Potentials (EPR) and Reaction Times (RT) in response to multiple target stimuli. In this study, within-trial relatively fast and slow sub averages are additionally examined, in 20 patients with schizophrenia and 20 age and sex matched controls. A conventional auditory oddball paradigm. Across-trial ERP average analysis showed smaller N200 amplitude and delayed latency (but larger P200 amplitude) in patients with schizophrenia compared with controls. Within-trial ERP analysis revealed a number of additional findings. Controls showed distinctive differences in fast compared with slow ERP sub averages (smaller P200 amplitude, increased N200/P300 amplitudes and earlier latencies). The schizophrenic group on the other hand, showed relatively similar fast versus slow subaverages (no differences in P200 amplitude and N200 latency). In addition, between-group (within-trial) analyses highlighted significant differences in earlier stages of processing (compared with across-trial averages) in both fast and slow subaverages (increased N100 amplitude in controls). The complementary within-trial (compared with across-trial) data are interpreted with respect to a possible disturbance in inhibitory function in patients with schizophrenia.
多项研究考察了跨试验平均晚期成分、事件相关电位（EPR）以及对多个目标刺激的反应时间（RT）。在本研究中，还对20名精神分裂症患者以及20名年龄和性别匹配的对照者进行了试验内相对快速和缓慢子平均值的研究。采用传统的听觉oddball范式。跨试验ERP平均分析显示，与对照组相比，精神分裂症患者的N200波幅较小且潜伏期延迟（但P200波幅较大）。试验内ERP分析还发现了一些其他结果。对照组在快速ERP子平均值与缓慢ERP子平均值之间显示出明显差异（P200波幅较小、N200/P300波幅增加且潜伏期更早）。另一方面，精神分裂症组在快速与缓慢子平均值之间表现出相对相似的情况（P200波幅和N200潜伏期无差异）。此外，组间（试验内）分析突出了在快速和缓慢子平均值的处理早期阶段（与跨试验平均值相比）的显著差异（对照组N100波幅增加）。关于精神分裂症患者抑制功能可能存在的干扰，对补充性的试验内（与跨试验相比）数据进行了解释。
