Migdalis I N, Gerolimou B, Kozanidou G, Hatzigakis S M, Karmaniolas K D
Department of Diabetes, NIMTS Hospital, Athens, Greece.
J Med. 1997;28(5-6):371-80.
An increased thickness of the carotid artery wall is thought to be a sign of early atherosclerosis. We have investigated the effects of fosinopril sodium in asymptomatic diabetic hypertensive subjects on the 12-month progression of arterial wall thickness. Forty non-insulin-dependent diabetics with hypertension and without hyperlipidemia were studied. After a 4-week run-in-diet phase, oral fosinopril sodium was administered (20 mg once daily) to 20 patients randomly selected, while 20 subjects were treated only with diet. The two groups were matched for age, sex, body mass index (BMI), duration of diabetes and glycemic control. Arterial wall thickness was measured as the mean of the maximum intimal-media thickness (IMT) in 16 carotid segments by B-mode ultrasound. The IMT increase over 12 months was 4.3% in the fosinopril sodium group vs 15.1% in subjects with diet. We conclude that fosinopril sodium treatment may be useful in decreasing the progression rate.
颈动脉壁厚度增加被认为是早期动脉粥样硬化的一个迹象。我们研究了福辛普利钠对无症状糖尿病高血压患者动脉壁厚度12个月进展情况的影响。研究了40名非胰岛素依赖型糖尿病合并高血压且无高脂血症的患者。在为期4周的饮食导入期后，随机选择20名患者口服福辛普利钠（每日一次，20毫克），而另外20名受试者仅接受饮食治疗。两组在年龄、性别、体重指数（BMI）、糖尿病病程和血糖控制方面相匹配。通过B型超声测量16个颈动脉节段的最大内膜中层厚度（IMT）平均值作为动脉壁厚度。福辛普利钠组12个月内IMT增加4.3%，而饮食治疗组为15.1%。我们得出结论，福辛普利钠治疗可能有助于降低进展速度。
