Sata M, Nakano H, Suzuki H, Noguchi S, Yamakawa Y, Tanaka E, Fukuizumi K, Tanaka K, Yoshida H, Tanikawa K
Second Department of Medicine, Kurume University School of Medicine, Japan.
J Gastroenterol. 1998 Apr;33(2):218-22. doi: 10.1007/s005350050073.
We conducted an epidemiological study of 509 residents of H town, Fukuoka, Japan, to investigate the high mortality rate from liver disease. Antibodies to hepatitis C virus (HCV) (anti-HCV) were detected in 120 residents (23.6%); HCV RNA in 91 (17.9%), and hepatitis B surface antigen (HBsAg) in 13 (2.6%). Multivariate logistic regression analyses showed that presence of anti-HCV, male gender, and history of liver disease were associated with the presence of liver dysfunction, and that age of more than 40 years and a particular district were associated with the presence of anti-HCV. HCV RNA was more frequently detected in anti-HCV-positive men than women (41, or 85.4% versus 50, or 69.4%) (P < 0.05). The incidence of liver dysfunction was significantly higher in HCV RNA-positive men than women (32, or 66.7% versus 22, or 30.6%) (P < 0.05). These findings suggest that: (1) HCV was correlated with the high mortality rate from liver diseases, (2) there were district-related differences in the incidence of HCV, and (3) the lower frequency of elimination of HCV from men may explain why they showed a high mortality from liver disease.
我们对日本福冈市H镇的509名居民进行了一项流行病学研究，以调查肝病的高死亡率。在120名居民（23.6%）中检测到丙型肝炎病毒（HCV）抗体（抗-HCV）；91名居民（17.9%）检测到HCV RNA，13名居民（2.6%）检测到乙型肝炎表面抗原（HBsAg）。多因素逻辑回归分析显示，抗-HCV的存在、男性性别和肝病病史与肝功能障碍的存在相关，40岁以上年龄和特定区域与抗-HCV的存在相关。抗-HCV阳性男性中检测到HCV RNA的频率高于女性（41例，占85.4%，而女性为50例，占69.4%）（P<0.05）。HCV RNA阳性男性肝功能障碍的发生率显著高于女性（32例，占66.7%，而女性为22例，占30.6%）（P<0.05）。这些发现表明：（1）HCV与肝病的高死亡率相关；（2）HCV的发病率存在区域相关差异；（3）男性清除HCV的频率较低，这可能解释了他们肝病死亡率高的原因。
