Sato Y, Matsunami M, Maruoka H, Honda Y, Inoue M, Oizumi K, Itoh A, Moriki Y
Futase Social Insurance Hospital, Iizuka, Japan.
Kurume Med J. 1994;41(1):41-50. doi: 10.2739/kurumemedj.41.41.
The incidence of hepatitis virus type C (HCV) in an area, Futase, of Iizuka city in Chikuho province in the northeastern part of Fukuoka prefecture in Kyushu, Japan, was estimated by screening sera for anti-HCV antibodies. Titers of anti human T-lymphotropic virus type I (HTLV-I) antibodies and hepatitis virus type B surface antigens (HBs) were also determined. The area of the present study is known to have a particularly high prevalence of chronic liver diseases, because coal mining was the key industry until a few decades ago. Also, in the old days it was rather isolated from the neighboring vicinities by surrounding mountains. The subjects of the present survey were 310 patients (117 males and 193 females) with various chronic diseases who visited Futase Social Insurance Hospital during a two year period from 1991 to 1992. Anti-HCV antibodies were detected in the sera of 55 patients, which is an overall positive rate of 18% (26% in male and 14% in female patients). This is extremely high compared to an estimated nationwide average positive rate of 1.6%. Even in 270 patients with normal liver function, the incidence was as high as 10%. The incidences were particularly high in groups of patients aged 40 through 49, 50 through 59 and 60 through 69, ranging from 20 to 23%, while they were as low as 13 and 17% in those aged 70 through 79 and 80 through 89 years, respectively. A high incidence, 57% was estimated for the patients with impaired liver function due to chronic liver diseases, especially in those concomitantly having diabetes mellitus (DM), 91%. The incidence of anti-HCV antibodies was the highest, 100%, in patients having both liver cirrhosis (LC) and DM. This was followed by those having chronic hepatitis (CH) and DM concomitantly and by those with LC alone, 86% each, and by those with CH alone 44%. Furthermore, the genotypes of the HCV in the sera of nine randomly selected carrier patients who had anti-HCV antibodies, even though they had diseases other than hepatic diseases and their liver functions were normal, were examined by the polymerase chain reaction method employing type-specific primers for DNA amplification. As a result, all the HCV strains were type II. On the other hand, there were no apparent differences in the incidences of HTLV-I in the area of the present study and in neighboring provinces of the same prefecture, Fukuoka.(ABSTRACT TRUNCATED AT 400 WORDS)
通过筛查血清中的抗丙型肝炎病毒（HCV）抗体，对日本九州福冈县东北部筑后地区饭冢市二濑区的丙型肝炎病毒（HCV）发病率进行了估算。同时还测定了抗人类I型嗜T淋巴细胞病毒（HTLV-I）抗体滴度和乙型肝炎病毒表面抗原（HBs）。已知本研究区域的慢性肝病患病率特别高，因为直到几十年前煤炭开采还是主要产业。而且，过去它因周围群山环绕而与周边地区相对隔绝。本次调查的对象是1991年至1992年期间在二濑社会保险医院就诊的310例患有各种慢性病的患者（男性117例，女性193例）。在55例患者的血清中检测到抗HCV抗体，总体阳性率为18%（男性患者为26%，女性患者为14%）。与估计的全国平均阳性率1.6%相比，这一比例极高。即使在270例肝功能正常的患者中，发病率也高达10%。40至49岁、50至59岁和60至69岁年龄组的发病率尤其高，在20%至23%之间，而70至79岁和80至89岁年龄组的发病率分别低至13%和17%。据估计，因慢性肝病导致肝功能受损的患者中发病率很高，为57%，尤其是同时患有糖尿病（DM）的患者，发病率为91%。在同时患有肝硬化（LC）和DM的患者中，抗HCV抗体的发病率最高，为100%。其次是同时患有慢性肝炎（CH）和DM的患者以及仅患有LC 的患者，各为86%，仅患有CH的患者为44%。此外，采用针对DNA扩增的型特异性引物的聚合酶链反应方法，对9例随机选择的抗HCV抗体携带者患者（尽管他们患有肝脏疾病以外的疾病且肝功能正常）血清中的HCV基因型进行了检测。结果显示，所有HCV毒株均为II型。另一方面，在本研究区域和同一县福冈的邻近省份，HTLV-I的发病率没有明显差异。（摘要截取自400字）
