Kertesz D A, Coulthart M B, Ryan J A, Johnson W M, Ashton F E
Bureau of Infectious Diseases, Laboratory Centre for Disease Control, Health Canada, Ottawa.
J Infect Dis. 1998 Jun;177(6):1754-7. doi: 10.1086/517439.
Invasive meningococcal disease is nationally reportable in Canada. In recent years, a serogroup C genotype, designated electrophoretic type 15 (ET15), has been the most frequently isolated meningococcal genotype in Canada and has caused epidemics across the country. Between August 1993 and September 1995, there were 9 cases of invasive meningococcal disease caused by a variant of this genotype, expressing group B capsular polysaccharide. The appearance of serogroup B:ET15 was related temporally and geographically to mass immunization campaigns designed to control serogroup C meningococcal disease in Canada. Since there is no vaccine available to control serogroup B meningococcal disease, the appearance of this variant may have public-health significance if it demonstrates the same epidemic potential as its serogroup C counterpart.
侵袭性脑膜炎球菌病在加拿大属于国家法定报告疾病。近年来，一种血清群C基因型，即电泳型15（ET15），一直是加拿大最常分离出的脑膜炎球菌基因型，并在全国引发了疫情。1993年8月至1995年9月期间，有9例侵袭性脑膜炎球菌病是由该基因型的一个变体引起的，该变体表达B群荚膜多糖。B群：ET15的出现与加拿大为控制C群脑膜炎球菌病而开展的大规模免疫运动在时间和地理上相关。由于目前尚无控制B群脑膜炎球菌病的疫苗，如果该变体表现出与其C群对应物相同的流行潜力，那么它的出现可能具有公共卫生意义。
