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与加拿大C群脑膜炎球菌病相关的脑膜炎奈瑟菌基因组指纹图谱

Genomic fingerprinting of Neisseria meningitidis associated with group C meningococcal disease in Canada.

作者信息

Strathdee C A, Tyler S D, Ryan J A, Johnson W M, Ashton F E

机构信息

National Laboratory for Special Pathogens, Bureau of Microbiology, Ottawa, Ontario, Canada.

出版信息

J Clin Microbiol. 1993 Sep;31(9):2506-8. doi: 10.1128/jcm.31.9.2506-2508.1993.

DOI:10.1128/jcm.31.9.2506-2508.1993
PMID:8408577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC265787/
Abstract

A single electrophoretic type (ET15) of Neisseria meningitidis has been associated with an increased incidence of group C meningococcal disease in Canada. Genomic fingerprinting through pulsed-field gel electrophoresis of chromosomal DNA was used to characterize the clonal relationship among meningococcal isolates of different electrophoretic types and among isolates within ET15. The genomic fingerprints of the ET15 isolates, while similar as a group, were sufficiently distinct to confirm linkage for four pairs of strains from focal outbreaks and differed markedly from those of the other common electrophoretic types, ET5, ET9, and ET21.

摘要

脑膜炎奈瑟菌的单一电泳型（ET15）与加拿大C群脑膜炎球菌病发病率增加有关。通过对染色体DNA进行脉冲场凝胶电泳的基因组指纹分析，来表征不同电泳型的脑膜炎球菌分离株之间以及ET15内分离株之间的克隆关系。ET15分离株的基因组指纹虽然作为一个群体相似，但足以确认来自局部暴发的四对菌株之间的联系，并且与其他常见电泳型ET5、ET9和ET21的指纹明显不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/514d/265787/89c4f3eb8b1a/jcm00021-0273-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/514d/265787/89c4f3eb8b1a/jcm00021-0273-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/514d/265787/89c4f3eb8b1a/jcm00021-0273-a.jpg

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