Yura S, Sagawa N, Mise H, Mori T, Masuzaki H, Ogawa Y, Nakao K
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Japan.
Am J Obstet Gynecol. 1998 May;178(5):926-30. doi: 10.1016/s0002-9378(98)70525-3.
We investigated the site of leptin production in the fetoplacental circulation.
We simultaneously determined plasma leptin levels in cord vessels and maternal peripheral veins of 38 healthy pregnant women. We also compared plasma leptin levels in 20 neonates at birth and on the fifth day after birth.
Leptin levels in cord vessels were significantly (p < 0.001) lower than those in maternal veins (mean 29.5 ng/ml). Leptin levels in umbilical arteries (mean 9.8 ng/ml) were significantly (p < 0.01) lower than those in umbilical veins (mean 12.9 ng/ml). Leptin levels in neonatal veins on the fifth day (mean 3.0 ng/ml) were markedly (p < 0.001) lower than those in umbilical arteries of the same neonates (mean 10.9 ng/ml).
The higher leptin levels in umbilical veins than in umbilical arteries and the marked decrease during the neonatal period suggest that the placenta is one of the major sources of leptin in the fetal circulation.
我们研究了胎儿 - 胎盘循环中瘦素的产生部位。
我们同时测定了38名健康孕妇脐带血管和母体外周静脉中的血浆瘦素水平。我们还比较了20名新生儿出生时及出生后第五天的血浆瘦素水平。
脐带血管中的瘦素水平显著低于母体静脉中的瘦素水平（p < 0.001）（平均29.5 ng/ml）。脐动脉中的瘦素水平（平均9.8 ng/ml）显著低于脐静脉中的瘦素水平（p < 0.01）（平均12.9 ng/ml）。出生后第五天新生儿静脉中的瘦素水平（平均3.0 ng/ml）显著低于同一新生儿脐动脉中的瘦素水平（p < 0.001）（平均10.9 ng/ml）。
脐静脉中的瘦素水平高于脐动脉，且在新生儿期显著下降，这表明胎盘是胎儿循环中瘦素的主要来源之一。
