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用于验证在广泛的吸入氧分数范围内气体交换测量的定量甲醇燃烧肺模型。

Quantitative methanol-burning lung model for validating gas-exchange measurements over wide ranges of FIO2.

作者信息

Miodownik S, Melendez J, Carlon V A, Burda B

机构信息

Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

出版信息

J Appl Physiol (1985). 1998 Jun;84(6):2177-82. doi: 10.1152/jappl.1998.84.6.2177.

DOI:10.1152/jappl.1998.84.6.2177
PMID:9609815
Abstract

The methanol-burning lung model has been used as a technique for generating a predictable ratio of carbon dioxide production (VCO2) to oxygen consumption (VO2) or respiratory quotient (RQ). Although an accurate RQ can be generated, quantitatively predictable and adjustable VO2 and VCO2 cannot be generated. We describe a new burner device in which the combustion rate of methanol is always equal to the infusion rate of fuel over an extended range of O2 concentrations. This permits the assembly of a methanol-burning lung model that is usable with O2 concentrations up to 100% and provides continuously adjustable and quantitative VO2 (69-1,525 ml/min) and VCO2 (46-1,016 ml/min) at a RQ of 0.667.

摘要

甲醇燃烧肺模型已被用作一种生成可预测的二氧化碳产生量(VCO2)与氧气消耗量(VO2)之比或呼吸商(RQ)的技术。尽管可以生成准确的RQ,但无法生成定量可预测且可调节的VO2和VCO2。我们描述了一种新的燃烧器装置,在该装置中,在较宽的氧气浓度范围内,甲醇的燃烧速率始终等于燃料的输注速率。这使得可以组装一个甲醇燃烧肺模型,该模型可在高达100%的氧气浓度下使用,并在RQ为0.667时提供连续可调且定量的VO2(69 - 1525毫升/分钟)和VCO2(46 - 1016毫升/分钟)。

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