Weinert T
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA.
Curr Opin Genet Dev. 1998 Apr;8(2):185-93. doi: 10.1016/s0959-437x(98)80140-8.
Eukaryotic checkpoint controls impose delays in the cell cycle in response to DNA damage or defects in DNA replication. Genetic and physiological studies in budding yeast have identified key genes and defined genetic pathways involved in checkpoint-mediated responses. Recent studies now lead to biochemical models that explain at least in part the arrest in G1 and delays during DNA replication after damage. Though progress in checkpoint controls has indeed been rapid, several observations identify puzzling aspects of checkpoint controls with few plausible explanations.
真核生物的检查点调控会在细胞周期中因DNA损伤或DNA复制缺陷而施加延迟。对芽殖酵母的遗传学和生理学研究已经确定了关键基因，并定义了参与检查点介导反应的遗传途径。最近的研究得出了一些生化模型，这些模型至少部分解释了G1期的停滞以及损伤后DNA复制过程中的延迟。尽管检查点调控方面的进展确实很快，但一些观察结果揭示了检查点调控中令人困惑的方面，且几乎没有合理的解释。
