Yagi M, Zieger B, Roth G J, Ware J
Research, Department of Veterans Affairs Puget Sound Health Care Center, Seattle, WA 98108, USA.
Gene. 1998 Jun 8;212(2):229-36. doi: 10.1016/s0378-1119(98)00146-2.
Septins are a family of highly conserved filament-forming proteins that have been shown to mediate cytokinesis and cytoskeletal organization in fungi and Drosophila. The gene encoding the human septin family member HCDCREL-1 has been shown to be transcribed from a locus immediately adjacent to that of the platelet glycoprotein (GP) Ib b. The HCDCREL-1 gene possesses a non-consensus polyadenylation signal that apparently is not efficiently utilized, resulting in the expression of a readthrough transcript also containing the platelet GPIb beta coding region. As a first step in understanding the regulation and function of HCDCREL-1, we have analyzed the structure of this gene and characterized its expression in a variety of human cells. Our results indicate that the gene is expressed at high levels in platelets and neural tissue, and is transcriptionally complex.
Septins是一类高度保守的丝状蛋白家族，已证明其在真菌和果蝇中介导胞质分裂和细胞骨架组织。编码人类septin家族成员HCDCREL-1的基因已被证明是从紧邻血小板糖蛋白（GP）Ibβ的位点转录而来。HCDCREL-1基因具有一个非一致性聚腺苷酸化信号，该信号显然未被有效利用，导致产生一种通读转录本，其也包含血小板GPIbβ编码区。作为了解HCDCREL-1调控和功能的第一步，我们分析了该基因的结构并对其在多种人类细胞中的表达进行了表征。我们的结果表明，该基因在血小板和神经组织中高水平表达，且转录复杂。
