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[长期黑暗作用下外侧膝状体神经元的变化(细胞化学研究)]

[Changes in the neurons of the lateral geniculate body under the effect of prolonged darkness (cytochemical study)].

作者信息

Busniuk M M

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(7):994-7.

PMID:961302
Abstract

With the aid of the cytospectrophotometry method the author studied the influence of light deprivation (the exposure of animals to darkness during 8 weeks following birth) on neurons of the dorsal nucleus of the external geniculate body of rats according to the index of glutamatedehydrogenase activity. It was established that unlike the visual cortex, separate groups of neurons which react differently to light deprivation, the majority of nervous cells in the external geniculate body demonstrate similar changes: a drop in the medium activity of glutamatdehydrogenase in neurons and its neurological satellites, a shift of neuron histograms according to this index to the left. These changes are accompanied by an increase of smaller neurons as compared to normal, as well as a drop in the amount of neurons with satellites. The found differences of reactions to light deprivation between the cortical neurons and switch areas of the visual analyzer are discussed in the light of functional traits of such neurons.

摘要

作者借助细胞分光光度法,根据谷氨酸脱氢酶活性指标,研究了光剥夺(出生后8周内将动物置于黑暗环境)对大鼠外侧膝状体背核神经元的影响。结果发现,与视皮层不同,外侧膝状体中对光剥夺反应不同的神经元群体,大多数神经细胞表现出相似的变化:神经元及其神经卫星中谷氨酸脱氢酶的平均活性下降,根据该指标神经元直方图向左偏移。这些变化伴随着比正常情况更小的神经元数量增加,以及有卫星的神经元数量减少。根据这些神经元的功能特性,讨论了皮层神经元和视觉分析器转换区域对光剥夺反应的差异。

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