B族链球菌III型多糖的免疫原性
Immunogenicity of polysaccharides from type III, group B Streptococcus.
作者信息
Baker C J, Edwards M S, Kasper D L
出版信息
J Clin Invest. 1978 Apr;61(4):1107-10. doi: 10.1172/JCI109011.
Abstract
The immunogenicity and safety of two polysaccharides isolated from type III, group B Streptococcus, were tested in adults selected for existing low concentrations of natural antibody to the capsular polysaccharide of this organism. Both vaccine preparations (trichloroacetic acid and EDTA) were found to lack pyrogenicity and toxicity for experimental animals. A single 50-microgram subcutaneous injection of either polysaccharide in human subjects elicited significant increase in antibody concentration in immunized compared with control individuals receiving phosphate-buffered saline. Antibody responses were maximal by 2 wk and remained at 21 wk after immunization. Vaccine-induced antibody was primarily of the IgG class. Of the two vaccines, the larger molecular size polysaccharide was significantly more immunogenic. Although no systemic reactions were recorded, mild transient local reactions occurred in 45% of vaccinees.
摘要
从B族链球菌III型分离出的两种多糖的免疫原性和安全性，在那些因对该生物体荚膜多糖天然抗体浓度较低而被挑选出的成年人中进行了测试。两种疫苗制剂（三氯乙酸和乙二胺四乙酸）对实验动物均无致热原性和毒性。在人类受试者中，单次皮下注射50微克的任何一种多糖，与接受磷酸盐缓冲盐水的对照个体相比，免疫个体的抗体浓度显著增加。免疫后2周时抗体反应达到最大值，并在21周时仍保持该水平。疫苗诱导的抗体主要为IgG类。在两种疫苗中，分子尺寸较大的多糖免疫原性明显更强。虽然未记录到全身反应，但45%的接种者出现了轻微的短暂局部反应。
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