Tavassoli M
Acta Anat (Basel). 1976;94(1):65-77. doi: 10.1159/000144545.
The postnatal development of bone marrow adipose cells was studied by sequential examination of marrow tissue obtained from the tibia and femur of 1- to 8-week-old rabbits. The bone marrow adipocyte begins to develop 2 weeks after birth. Its cellular origin differs from the "fibroblast-like" cell that is the progenitor of the extramedullary adipocyte. The marrow pre-adipocyte is associated with the sinus endothelium and adventitial cells, but is not associated with collagen and does not contain abundant organized rough endoplasmic reticulum. Unlike the extramedullary adipocyte, the course of differentiation of the medullary adipocyte is not characterized by the appearance of glycogen; furthermore, during the coalescence of lipid droplets to form larger fat globules, cytoplasmic organelles, such as mitochondria and ribosomes, are trapped within the lipid substance to form intralipid vacuoles containing degraded cytoplasmic organelles. The possible significance of these morphologic differences between the developing bone marrow adipocyte and that of its extramedullary counterpart is discussed.
通过对1至8周龄兔子胫骨和股骨骨髓组织的连续检查，研究了骨髓脂肪细胞的出生后发育情况。骨髓脂肪细胞在出生后2周开始发育。其细胞起源不同于作为髓外脂肪细胞祖细胞的“成纤维细胞样”细胞。骨髓前脂肪细胞与窦内皮和外膜细胞相关，但与胶原蛋白无关，且不含有丰富的有组织的粗面内质网。与髓外脂肪细胞不同，髓内脂肪细胞的分化过程没有糖原出现的特征；此外，在脂滴聚合并形成更大的脂肪球的过程中，细胞质细胞器，如线粒体和核糖体，被困在脂质物质中，形成含有降解细胞质细胞器的脂质内空泡。讨论了发育中的骨髓脂肪细胞与其髓外对应物之间这些形态学差异的可能意义。
