Bigelow C L, Tavassoli M
Acta Anat (Basel). 1984;118(1):60-4. doi: 10.1159/000145823.
The developmental pattern of red and yellow bone marrow was studied in rabbits of different ages from newborn to 6 months of age. At birth no adipose cells were seen in any of the marrow cavities. Most bones were still developing and marrow cavities were relatively limited. Nonetheless a distinct difference in the cellularity of marrow in the trunk versus limb bones was noted, the latter being significantly less cellular. Adipose cells began to develop at 2 weeks of age and proceeded so that the adult pattern of red and yellow marrow was fully established by 4 months. The development of adipose cells occurred in both trunk and limb bones; the magnitude of the process, however, was considerably greater in the limb bones. Adipocyte precursors may be present in the marrow at birth with a differential distribution in the areas of prospective red and yellow marrow. Thus, fatty involution of marrow appears to be a programmed developmental event.
研究了从新生到6个月大的不同年龄兔子的红骨髓和黄骨髓的发育模式。出生时，在任何骨髓腔中均未见到脂肪细胞。大多数骨骼仍在发育，骨髓腔相对有限。尽管如此，仍注意到躯干骨与四肢骨骨髓细胞性存在明显差异，四肢骨的细胞明显较少。脂肪细胞在2周龄时开始发育，并持续发育，以至于到4个月时红骨髓和黄骨髓的成人模式完全建立。脂肪细胞的发育发生在躯干骨和四肢骨中；然而，该过程在四肢骨中的程度要大得多。脂肪细胞前体可能在出生时就存在于骨髓中，在前瞻性红骨髓和黄骨髓区域分布不同。因此，骨髓的脂肪退化似乎是一个程序性发育事件。
