Csernansky J G, Grace A A
Washington University School of Medicine, Metropolitan St. Louis Psychiatric Center, MO 63110, USA.
Schizophr Bull. 1998;24(2):185-7. doi: 10.1093/oxfordjournals.schbul.a033319.
New models of the pathogenesis of schizophrenia are presented. These models represent hypotheses intended to stimulate discussion and new experimentation. Each of the contributions approach the pathophysiology of schizophrenia from a unique perspective. Yet, all of them emphasize the integration of new advances in basic neuroscience, the functional neuroanatomy of schizophrenia, and information drawn from new biotechnologies, such as neuroimaging and molecular genetics, to provide unique insights into schizophrenia. In each case, the novel hypotheses proposed also illustrate the continuing need for a better understanding of the dynamic interaction between synaptic plasticity and neural circuitry to further our understanding of the human brain in health and disease.
本文提出了精神分裂症发病机制的新模型。这些模型代表了旨在激发讨论和新实验的假说。每篇论文都从独特的视角探讨精神分裂症的病理生理学。然而，它们都强调将基础神经科学的新进展、精神分裂症的功能性神经解剖学以及从神经影像学和分子遗传学等新生物技术中获取的信息整合起来，以提供对精神分裂症的独特见解。在每种情况下，所提出的新假说也表明，持续需要更好地理解突触可塑性与神经回路之间的动态相互作用，以加深我们对健康和疾病状态下人类大脑的理解。
