Ishihara T, Uchino F, Takahashi M
Acta Pathol Jpn. 1976 May;26(3):357-66. doi: 10.1111/j.1440-1827.1976.tb00885.x.
Amyloid in freeze-etched specimen of liver of mice receiving subcutaneous in sodium caseinate was studied morphologically. The convex surface and cross surface of amyloid nodule were noted. The three dimentional structure of the amyloid fibrils which showed felt-like structure, globular profiles among amyloid fibrils and amyloid bundles were clearly visible. Amyloid bundles enveloped by the cytoplasmic membrane of the Kupffer cell projected from the deeply concave surface of the cytoplasmic membrane into the Disse's space and showed the appearance of ston-column-like structure. The amyloid bundles projecting from the invaginated cytoplasmic membrane were closely in contact with the cytoplasmic membrane and deeply rooted in the cytoplasm of the Kupffer cell.
对接受酪蛋白酸钠皮下注射的小鼠肝脏冷冻蚀刻标本中的淀粉样蛋白进行了形态学研究。观察到淀粉样蛋白结节的凸面和横断面。淀粉样蛋白原纤维的三维结构清晰可见，呈现毡状结构、原纤维间的球状轮廓以及淀粉样蛋白束。被库普弗细胞胞质膜包裹的淀粉样蛋白束从胞质膜的深凹面伸入狄氏间隙，呈现石柱样结构外观。从内陷胞质膜伸出的淀粉样蛋白束与胞质膜紧密接触，并深深扎根于库普弗细胞的细胞质中。
