Spier S A
University of Maryland School of Medicine, Baltimore 21202-2165, USA.
Depress Anxiety. 1998;7(2):73-5.
Because of reported efficacy of combining classes of antidepressants, 25 patients were treated with bupropion in combination with SRI's and venlafaxine. Fifteen patients inadequately responsive to monotherapy received combination treatment; ten patients without residual symptoms received adjunctive bupropion to treat SRI- or venlafaxine-induced side effects. Fourteen subjects (56%) responded, 11 (44%) did not. Twelve of 15 subjects receiving combination treatment to boost the effects of monotherapy responded, while only 2 of 10 subjects receiving combination treatment for side effects responded. Combination therapy was well tolerated even by geriatric and "medically frail" patients.
由于有报道称联合使用不同类别的抗抑郁药具有疗效，25名患者接受了安非他酮与选择性5-羟色胺再摄取抑制剂（SRI）及文拉法辛联合治疗。15名对单一疗法反应欠佳的患者接受了联合治疗；10名没有残留症状的患者接受了辅助性安非他酮治疗，以处理SRI或文拉法辛引起的副作用。14名受试者（56%）有反应，11名（44%）无反应。15名接受联合治疗以增强单一疗法效果的受试者中有12名有反应，而10名接受联合治疗以处理副作用的受试者中只有两名有反应。联合疗法甚至老年患者和“身体虚弱”的患者也能很好耐受。
