Nardone G, Rocco A, Budillon G
Chair of Gastroenterology, University of Naples, Italy.
Ital J Gastroenterol Hepatol. 1998 Feb;30(1):134-7.
The cause of inflammatory bowel disease is still unknown although several bacterial and viral agents have been implicated in their aetiologies. Helicobacter pylori infection, the main cause of gastroduodenal diseases, could, theoretically, be involved in the pathogenesis of inflammatory bowel disease. In fact, it induces permeability alterations and immunological derangements in the stomach similar to those detected in the colon of inflammatory bowel disease patients. However, epidemiological data do not support this hypothesis and recent evidence even points to a low prevalence of Helicobacter pylori in inflammatory bowel disease. These data are discussed in the light of possible confounding factors.
尽管有几种细菌和病毒因子被认为与炎症性肠病的病因有关，但其病因仍不清楚。幽门螺杆菌感染是胃十二指肠疾病的主要原因，从理论上讲，它可能参与炎症性肠病的发病机制。事实上，它在胃中引起的通透性改变和免疫紊乱与在炎症性肠病患者结肠中检测到的情况相似。然而，流行病学数据并不支持这一假设，最近的证据甚至表明幽门螺杆菌在炎症性肠病中的患病率较低。根据可能的混杂因素对这些数据进行了讨论。
