Elkarim R A, Mustafa M, Kivisäkk P, Link H, Bakhiet M
Huddinge University Hospital, Stockholm, Sweden.
Eur J Clin Invest. 1998 Apr;28(4):295-9. doi: 10.1046/j.1365-2362.1998.00279.x.
We have recently described the induction of anti-cytokine autoantibodies during bacterial infections and autoimmune diseases as a mechanism for cytokine regulation.
Herein, we study the occurrence of autoantibodies to pro- and anti-inflammatory cytokines in cerebrospinal fluid and plasma from patients with multiple sclerosis, aseptic meningitis and stroke.
Increased levels of autoantibodies to interferon gamma, tumour necrosis factor alpha, interleukin 4 and interleukin 10 were detected in both compartments of multiple sclerosis and aseptic meningitis patients. Interestingly, in cerebrospinal fluid from stroke patients, only autoantibodies to interleukin 4 and interleukin 10, but not interferon alpha or tumour necrosis factor alpha were detected. No significant autoantibody levels were registered in plasma from stroke patients against all four cytokines compared with healthy control subjects. The latter revealed very low autoantibody levels in plasma and no detectable autoantibodies in cerebrospinal fluid.
Our data show for the first time the occurrence of cytokine autoantibodies in these diseases, but their biological significance is unclear.
我们最近描述了在细菌感染和自身免疫性疾病期间抗细胞因子自身抗体的诱导作为细胞因子调节的一种机制。
在此，我们研究了多发性硬化症、无菌性脑膜炎和中风患者脑脊液和血浆中促炎和抗炎细胞因子自身抗体的发生情况。
在多发性硬化症和无菌性脑膜炎患者的两个样本中均检测到γ干扰素、肿瘤坏死因子α、白细胞介素4和白细胞介素10自身抗体水平升高。有趣的是，在中风患者的脑脊液中，仅检测到白细胞介素4和白细胞介素10自身抗体，而未检测到α干扰素或肿瘤坏死因子α自身抗体。与健康对照受试者相比，中风患者血浆中针对所有四种细胞因子均未检测到显著的自身抗体水平。后者在血浆中显示出非常低的自身抗体水平，且在脑脊液中未检测到自身抗体。
我们的数据首次显示了这些疾病中细胞因子自身抗体的存在，但其生物学意义尚不清楚。
