Rose D P, Leklem J E, Brown R R, Potera C
Am J Clin Nutr. 1976 Sep;29(9):956-60. doi: 10.1093/ajcn/29.9.956.
Plasma alanine or glycine concentrations and blood pyruvate were studied before and after oral administration of the two amino acids to women using estrogen-containing oral contraceptives and to a control group of women. Thirty oral contraceptive users and 14 controls received alanine loads (200 mg/kg of body weight). The two groups had similar fasting plasma alanine levels, but the fasting blood pyruvate was elevated in the contraceptive steroid-treated women. After alanine ingestion, the increases in plasma alanine were significantly lower in the oral contraceptive users. Both groups showed a rise in blood pyruvate; there were no differences in the increments above fasting values. Treatment with pyridoxine hydrochloride, 25 mg for 4 weeks, had not effect on the responses of 11 oral contraceptive users to alanine loading. Twenty-four oral contraceptive users and 14 controls were studied before and after a glycine load (140 mg/kg of body weight). The fasting plasma glycine levels were similar, but lesser increases after ingestion of the amino acid occurred in the oral contraceptive-treated group. Blood pyruvate concentrations in both oral contraceptive users and controls were unaffected by oral glycine loads.
对使用含雌激素口服避孕药的女性和对照组女性口服这两种氨基酸前后的血浆丙氨酸或甘氨酸浓度以及血液丙酮酸进行了研究。30名口服避孕药使用者和14名对照组人员接受了丙氨酸负荷（200毫克/千克体重）。两组的空腹血浆丙氨酸水平相似，但接受避孕类固醇治疗的女性空腹血液丙酮酸水平升高。摄入丙氨酸后，口服避孕药使用者血浆丙氨酸的升高幅度明显较低。两组血液丙酮酸均出现升高；高于空腹值的增幅没有差异。对11名口服避孕药使用者服用25毫克盐酸吡哆醇，持续4周，对其丙氨酸负荷反应没有影响。对24名口服避孕药使用者和14名对照组人员在口服甘氨酸负荷（140毫克/千克体重）前后进行了研究。空腹血浆甘氨酸水平相似，但口服避孕药治疗组摄入氨基酸后的升高幅度较小。口服避孕药使用者和对照组的血液丙酮酸浓度均不受口服甘氨酸负荷的影响。
