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Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets.

作者信息

Hill R S, Cruise G M, Hager S R, Lamberti F V, Yu X, Garufis C L, Yu Y, Mundwiler K E, Cole J F, Hubbell J A, Hegre O D, Scharp D W

机构信息

Neocrin Company, Irvine, California 92718, USA.

出版信息

Ann N Y Acad Sci. 1997 Dec 31;831:332-43. doi: 10.1111/j.1749-6632.1997.tb52208.x.

DOI:10.1111/j.1749-6632.1997.tb52208.x
PMID:9616725
Abstract

Functional porcine islets, free of known pathogens, can serve as a source of insulin producing cells for the treatment of experimentally induced insulin dependent Diabetes Mellitus. Porcine islets can be conformally coated (microencapsulated) with a covalently linked, stable permselective membrane while maintaining islet viability and function. The PEG conformal coating is immunoprotective in a discordant xenograft animal model (porcine islets to rat).

摘要

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