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[精索静脉曲张及其对不育症的影响。手术干预的适应症和局限性]

[Varicocele and its repercussion on infertility. Indications and limitations of surgical intervention].

作者信息

Austoni E, Cazzaniga A, Gatti G, Baroni P, Gentilini O, Levorato C A

机构信息

Ospedale S. Giuseppe, Divisione di Urologia, Milano.

出版信息

Arch Ital Urol Androl. 1998 Apr;70(2):103-7.

PMID:9616987
Abstract

According to different Authors, varicocele incidence in unselected population fluctuates from 8 to 22% but in selected population affected by sterility incidence ranges from 21 to 39%. However other Authors have demonstrated that about 50% of patients suffering from varicocele have semen alterations. Various mechanisms have been suggested for testicular dysfunction associated with varicocele: intrascrotal hyperthermia, reflux of renal and adrenal metabolites from the renal vein and hypoxia. The most important semen alterations are observed in patients suffering from grade 2 and 3 varicocele and especially these patients must undergo surgical operation. According to recent findings, better results about the improvement of semen quality are obtained by operating children in puberal age. This clinical approach allows a prevention of testicular hypotrophy or, when this is already present, its reversibility. Varicocele surgical treatment makes use of traditional techniques microsurgical or not and mininvasive techniques. After renouncing of intrascrotal varicocelectomy, traditional techniques provide ligature and section of ectasic spermatic veins, after a surgical high (at level of the internal inguinal ring) or low (over inguinal canal) skin incision. Microsurgery allows recognition and protection of lymphatic and arterial vessels and execution of microsurgical anastomosis between venous spermatic and ileo-femoral circle vessels, when this is necessary. Internal spermatic vessels and vas deferens can be visualized through the laparoscope and so laparoscopic varicocele treatment was suggested. These new techniques and traditional operation are burdened with the same percentage of relapses but in laparoscopic procedure complications are more important. Recently radiographic occlusion techniques are also utilized (internal spermatic vein retrograde scleroembolization); the percentage of relapses is between 4 and 11%, with no risk of postvaricocelectomy hydrocele but with risk of loss of kidney (migration of the ballon or coil into the renal vein). Surgical treatment of varicocele produces a significant improvement in semen analysis in 60 to 80 per cent of patients affected by testicular dysfunction. Pregnancy rates after varicocelectomy are including from 20 to 60 per cent with most series averaging about 35 per cent.

摘要

根据不同作者的研究,在未经选择的人群中,精索静脉曲张的发病率在8%至22%之间波动,但在患有不育症的特定人群中,发病率在21%至39%之间。然而,其他作者已经证明,约50%的精索静脉曲张患者存在精液改变。对于与精索静脉曲张相关的睾丸功能障碍,已经提出了各种机制:阴囊内高温、肾静脉和肾上腺代谢产物从肾静脉反流以及缺氧。在患有2级和3级精索静脉曲张的患者中观察到最重要的精液改变,尤其是这些患者必须接受手术。根据最近的研究结果,对青春期儿童进行手术能更好地改善精液质量。这种临床方法可以预防睾丸萎缩,或者在睾丸萎缩已经存在时实现其逆转。精索静脉曲张的手术治疗采用传统技术(无论是否为显微手术)和微创技术。在放弃阴囊内精索静脉结扎术后,传统技术在高位(腹股沟内环水平)或低位(腹股沟管上方)皮肤切口后,对扩张的精索静脉进行结扎和切断。显微手术能够识别和保护淋巴管和动脉血管,并在必要时在精索静脉和髂股循环血管之间进行显微手术吻合。通过腹腔镜可以看到精索内血管和输精管,因此有人提出了腹腔镜精索静脉曲张治疗方法。这些新技术和传统手术的复发率相同,但腹腔镜手术的并发症更为严重。最近也采用了放射学闭塞技术(精索内静脉逆行硬化栓塞术);复发率在4%至11%之间,没有精索静脉结扎术后鞘膜积液的风险,但有肾损伤风险(球囊或线圈迁移至肾静脉)。精索静脉曲张的手术治疗使60%至80%受睾丸功能障碍影响的患者精液分析有显著改善。精索静脉结扎术后的妊娠率在20%至60%之间,大多数系列平均约为35%。

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