Yumita N, Sasaki K, Umemura S, Yukawa A, Nishigaki R
School of Pharmaceutical Science, Toho University, Funabashi, Chiba, Japan.
Cancer Lett. 1997 Jan 15;112(1):79-86. doi: 10.1016/s0304-3835(96)04548-x.
The antitumor effect of a gallium-porphyrin complex, ATX-70, induced by focused ultrasound, on colon 26 carcinoma implanted in a mouse kidney was investigated. Colon 26 tumors were exposed to focused ultrasound at 500 kHz and 1 MHz in a progressive wave mode. Both frequency components were superimposed onto each other in the focal zone to efficiently produce cavitation in the tumor. ATX-70 was administered intravenously at the dose of 2.5 mg/kg, 24 h before the ultrasonic exposure. Antitumor effects were evaluated by histological observation 7 days after the exposure. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with ATX-70, while neither the treatment with ATX-70 alone nor that with ultrasound alone caused any necrosis. These results first demonstrated that antitumor effects of a porphyrin compound can be induced by focused ultrasound in a progressive wave mode.
研究了聚焦超声诱导的镓卟啉配合物ATX-70对植入小鼠肾脏的结肠26癌的抗肿瘤作用。结肠26肿瘤在500kHz和1MHz频率下以连续波模式接受聚焦超声照射。两个频率成分在焦点区域相互叠加，以在肿瘤中有效产生空化。在超声照射前24小时，以2.5mg/kg的剂量静脉注射ATX-70。照射7天后通过组织学观察评估抗肿瘤效果。联合ATX-70进行超声治疗时观察到肿瘤组织的破坏，而单独使用ATX-70或单独使用超声治疗均未引起任何坏死。这些结果首次表明，连续波模式的聚焦超声可诱导卟啉化合物产生抗肿瘤作用。
