Maruyama M, Asano T, Uematsu T, Nakagohri T, Hasegawa M, Miyauchi H, Iwashita C, Isono K
Second Department of Surgery, Chiba University School of Medicine.
Jpn J Cancer Res. 1995 Sep;86(9):800-1. doi: 10.1111/j.1349-7006.1995.tb03088.x.
The antitumor effects of high-energy shock waves (HESW) in combination with ATX-70 [a gallium-porphyrin complex, 2,4-bis(1-decyloxyethyl)-Ga(III)-1,3,5,8-tetramethylporphyrin++ +-6, 7-dipropionyl diaspartic acid [sequence: see text] were investigated. In vitro, the cell damage to mouse MH134 hepatoma after HESW treatment was enhanced by adding ATX-70. In vivo, HESW and ATX-70 combination therapy inhibited cell growth. However, neither HESW treatment alone nor ATX-70 treatment alone inhibited cell growth. These results imply that the antitumor effects of HESW and ATX-70 combined therapy are caused by activation of ATX-70 by HESW.
研究了高能冲击波（HESW）与ATX - 70[一种镓卟啉配合物，2,4 - 双（1 - 癸氧基乙基）- Ga（III）- 1,3,5,8 - 四甲基卟啉++ + - 6,7 - 二丙酰二天冬氨酸[序列：见原文]联合使用时的抗肿瘤作用。在体外，添加ATX - 70可增强HESW处理后对小鼠MH134肝癌细胞的损伤。在体内，HESW与ATX - 70联合治疗可抑制细胞生长。然而，单独的HESW治疗或单独的ATX - 70治疗均不能抑制细胞生长。这些结果表明，HESW与ATX - 70联合治疗的抗肿瘤作用是由HESW激活ATX - 70所致。
