Mary C, Marois Y, King M W, Laroche G, Douville Y, Martin L, Guidoin R
Quebec Biomaterials Institute, Inc., Centre Hospitalier Universitaire de Québec, Canada.
ASAIO J. 1998 May-Jun;44(3):199-206. doi: 10.1097/00002480-199805000-00015.
To find a nonabsorbable suture material that is equivalent to polypropylene in ease of handling and tensile properties, and that has low thrombogenicity and tissue reactivity but improved biostability, some researchers and clinicians see merit in considering the suitability of monofilaments made from polyvinylidene fluoride. The current animal study investigated the relative biocompatibility and biostability of these two suture materials by using them to anastomose a polyester arterial prosthesis in a canine thoracoabdominal bypass model for 10 periods of implantation ranging from 4 hr to 2 years. Biocompatibility was assessed with light and scanning electron microscope examinations of the explanted sutures, and biostability of the cleaned sutures was determined by Fourier transform infrared spectroscopy and scanning electron microscope analysis. The polyvinylidene fluoride and polypropylene sutures were found to have similar handling and healing characteristics. During the first months in vivo, both types of suture experienced a temporary increase in carbonyl group absorption that coincided with the duration of the inflammatory response. After 1 and 2 years in vivo, the explanted polypropylene sutures showed visual evidence of surface stress cracking. This was not found with the explanted polyvinylidene fluoride sutures. These results suggest that polyvinylidene fluoride may be more biostable than polypropylene in the long term.
为了找到一种在操作简便性和拉伸性能方面与聚丙烯相当，且具有低血栓形成性和组织反应性但生物稳定性有所改善的不可吸收缝合材料，一些研究人员和临床医生认为考虑聚偏二氟乙烯制成的单丝的适用性具有一定价值。当前的动物研究通过在犬胸腹旁路模型中使用这两种缝合材料对聚酯动脉假体进行吻合，植入时间从4小时到2年，共10个时间段，来研究这两种缝合材料的相对生物相容性和生物稳定性。通过对取出的缝合线进行光学显微镜和扫描电子显微镜检查来评估生物相容性，通过傅里叶变换红外光谱和扫描电子显微镜分析来确定清洁后的缝合线的生物稳定性。结果发现聚偏二氟乙烯和聚丙烯缝合线具有相似的操作和愈合特性。在体内的最初几个月里，两种类型的缝合线的羰基吸收都出现了暂时增加，这与炎症反应的持续时间一致。在体内植入1年和2年后，取出的聚丙烯缝合线有表面应力开裂的明显迹象。而取出的聚偏二氟乙烯缝合线未发现这种情况。这些结果表明，从长期来看，聚偏二氟乙烯可能比聚丙烯具有更高的生物稳定性。
