Karim F, Hainsworth R
Am J Physiol. 1976 Aug;231(2):434-40. doi: 10.1152/ajplegacy.1976.231.2.434.
In chloralose-anesthetized dogs the abdominal circulation was vascularly isolated without opening the abdominal cavity. The region was perfused at constant flow through the aorta and drained at constant pressure from the inferior vena cava. Changes in resistance were calculated from changes in perfusion pressure and changes in capacitance were calculated by integrating changes in venous outflow. Stimulation of both splanchnic nerves at 20 Hz increased resistance by 135% and reduced capacitance by 7.20 ml kg-1. The capacitance responses at 1 and 2 Hz (3.42 and 5.43 ml kg-1) were 48 and 67% of the responses at 20 Hz, However, the resistance responses at 1 and 2 Hz (14 and 31% increase) were only 12 and 26% of the responses at 20 Hz. After occlusion of the splenic pedicle, capacitance responses were reduced by about 40%. Although changes in inferior vena caval pressure changed the volume of blood in the abdomen by 0.92 ml kg-1 cmH2O-1, the responses to stimulation were relatively constant in any one animal at constant venous pressures between 5 and 15 cmH2O.
在水合氯醛麻醉的犬中，在不打开腹腔的情况下对腹部循环进行血管分离。通过主动脉以恒定流量灌注该区域，并通过下腔静脉以恒定压力引流。根据灌注压力的变化计算阻力变化，通过对静脉流出量的变化进行积分来计算电容变化。以20Hz频率刺激双侧内脏神经可使阻力增加135%，电容减少7.20ml·kg⁻¹。1Hz和2Hz时的电容反应（分别为3.42和5.43ml·kg⁻¹）分别为20Hz时反应的48%和67%，然而，1Hz和2Hz时的阻力反应（分别增加14%和31%）仅为20Hz时反应的12%和26%。脾蒂阻断后，电容反应降低约40%。尽管下腔静脉压力的变化使腹部血液量改变0.92ml·kg⁻¹·cmH₂O⁻¹，但在任何一只动物中，在5至15cmH₂O的恒定静脉压力下，对刺激的反应相对恒定。
