Katoh C
Department of Ophthalmology, Hirosaki University School of Medicine, Aomori-ken, Japan.
Nippon Ganka Gakkai Zasshi. 1998 May;102(5):307-11.
To study the role of arterial blood dynamics in the thrombogenesis of thrombin-induced experimental retinal vein obstruction, the retinal blood flow velocity was evaluated using scanning laser ophthalmoscopic fluorescein videoangiography in an experimental rabbit retinal vein obstruction model. Retinal vein obstruction was made by transadventitial direct instillation of thrombin to the retinal vessels from the vitreous side. The blood flow velocity in the retinal artery and vein was estimated by measuring the passing velocity of the flow head of the dye bolus and venous filling time, respectively. 23 animals were treated with thrombin and compared with 18 controls not treated. In the control group retinal artery blood flow velocity and retinal venous fluorescein filling time was 5.3 +/- 1.1 mm/sec (mean +/- standard deviation) and 6.2 +/- 1.2 sec, respectively. In the treated group the values were 5.7 +/- 1.3 mm/sec and 5.8 +/- 1.0 sec before the thrombin administration, and 3.0 +/- 0.9 mm/sec at 24 hours after its administration, and 5.7 +/- 2.0 sec and 4.0 +/- 1.5 mm/sec and 4.5 +/- 1.4 sec at 48 hours after the administration. These results indicate that a decrease in retinal artery blood flow velocity is strongly involved in the thrombogenesis in thrombin-induced experimental retinal vein obstruction.
为研究动脉血流动力学在凝血酶诱导的实验性视网膜静脉阻塞血栓形成中的作用，在实验性兔视网膜静脉阻塞模型中，使用扫描激光眼底荧光血管造影术评估视网膜血流速度。通过从玻璃体侧经外膜直接向视网膜血管滴注凝血酶来制造视网膜静脉阻塞。分别通过测量染料团流头的通过速度和静脉充盈时间来估计视网膜动脉和静脉中的血流速度。23只动物接受凝血酶治疗，并与18只未治疗的对照组进行比较。在对照组中，视网膜动脉血流速度和视网膜静脉荧光素充盈时间分别为5.3±1.1毫米/秒（平均值±标准差）和6.2±1.2秒。在治疗组中，凝血酶给药前的值分别为5.7±1.3毫米/秒和5.8±1.0秒，给药后24小时为3.0±0.9毫米/秒，给药后48小时为5.7±2.0秒、4.0±1.5毫米/秒和4.5±1.4秒。这些结果表明，视网膜动脉血流速度降低与凝血酶诱导的实验性视网膜静脉阻塞血栓形成密切相关。
