Agurs-Collins T, Kim K S, Dunston G M, Adams-Campbell L L
Howard University Cancer Center, Division of Epidemiology and Biostatistics, Washington, DC 20060, USA.
J Cancer Res Clin Oncol. 1998;124(3-4):186-90. doi: 10.1007/s004320050153.
The purpose of this study was to examine the relationship between plasma lipid and lipoprotein levels, stage of disease and breast cancer risk in African-American women. The study population comprised 163 African-American women: patients (n = 58) and controls (n = 105), with mean ages of 57.2 years and 47.7 years respectively. Approximately 71% and 56% of the women with breast cancer and the control population, respectively, were postmenopausal. Those with cancer had significantly higher education levels, P < or = 0.01, and higher triglyceride levels compared to the controls, P < or = 0.001, but lower body mass index (BMI) levels, P < or = 0.01. There were no statistically significant differences observed in total cholesterol, high-density-lipoprotein-containing cholesterol and low-density-lipoprotein-containing cholesterol between the patients and controls. After adjustments for age, education, BMI, and menopausal status, triglycerides remained significantly and positively associated with breast cancer risk. The significant correlation between the high levels of triglycerides and breast cancer risk (odds ratio = 5.12) may be attributed to differences in lipid metabolism between the women with breast cancer and controls, or to the consequences of breast cancer.
本研究的目的是探讨非裔美国女性血浆脂质和脂蛋白水平、疾病分期与乳腺癌风险之间的关系。研究人群包括163名非裔美国女性：患者（n = 58）和对照组（n = 105），平均年龄分别为57.2岁和47.7岁。分别约有71%的乳腺癌女性和56%的对照人群处于绝经后状态。与对照组相比，癌症患者的教育水平显著更高（P≤0.01），甘油三酯水平更高（P≤0.001），但体重指数（BMI）水平更低（P≤0.01）。患者与对照组之间在总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇方面未观察到统计学上的显著差异。在对年龄、教育程度、BMI和绝经状态进行调整后，甘油三酯仍与乳腺癌风险显著正相关。甘油三酯水平升高与乳腺癌风险之间的显著相关性（优势比 = 5.12）可能归因于乳腺癌女性与对照组之间脂质代谢的差异，或归因于乳腺癌的后果。
