Dinarello C A, Novick D, Puren A J, Fantuzzi G, Shapiro L, Mühl H, Yoon D Y, Reznikov L L, Kim S H, Rubinstein M
University of Colorado Health Sciences Center, Denver 80262, USA.
J Leukoc Biol. 1998 Jun;63(6):658-64.
Initially described in 1989 as interferon-gamma (IFN-gamma) inducing factor (IGIF), interleukin-18 (IL-18) is a novel pro-inflammatory cytokine that is clearly more than an inducer of IFN-gamma. The cytokine possesses several biological properties such as activation of nuclear factor-kappaB (NF-kappaB), Fas ligand expression, the induction of both CC and CXC chemokines, and increased production of competent human immunodeficiency virus. Most activities are due to a receptor complex that recruits the IL-1 receptor-activating kinase (IRAK), leading to translocation of NF-kappaB. This property and others support the concept that IL-18 is related to the IL-1 family. Indeed, one of the IL-18 receptor chains is the IL-1 receptor-related protein, a member of the IL-1R family. In addition, IL-18 is structurally similar to IL-1beta and like IL-1beta is first synthesized as a leaderless precursor requiring the IL-1beta converting enzyme for cleavage into an active molecule. The biology of IL-18 is reviewed in the overview and the implication for a role for this cytokine in disease is presented.
白细胞介素-18（IL-18）最初于1989年被描述为干扰素-γ（IFN-γ）诱导因子（IGIF），它是一种新型促炎细胞因子，显然不仅仅是IFN-γ的诱导剂。该细胞因子具有多种生物学特性，如激活核因子-κB（NF-κB）、Fas配体表达、诱导CC和CXC趋化因子以及增加有活性的人类免疫缺陷病毒的产生。大多数活性是由于一种受体复合物招募了白细胞介素-1受体激活激酶（IRAK），导致NF-κB易位。这一特性及其他特性支持了IL-18与IL-1家族相关的概念。事实上，IL-18受体链之一是IL-1受体相关蛋白，它是IL-1R家族的成员。此外，IL-18在结构上与IL-1β相似，并且与IL-1β一样，最初是以无信号肽前体的形式合成的，需要IL-1β转换酶将其切割成活性分子。本文在概述中对IL-18的生物学特性进行了综述，并阐述了该细胞因子在疾病中的作用。
