Braat J P, Mulder P G, Fokkens W J, van Wijk R G, Rijntjes E
Departments of Ear, Nose and Throat Surgery, Biostatistics, and Allergology, Erasmus University Rotterdam and University Hospital 'Dijkzigt,' Rotterdam.
Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1748-55. doi: 10.1164/ajrccm.157.6.9701016.
The objective of the study was to compare cold dry air (CDA) and histamine in differentiating patients with nonallergic noninfectious perennial rhinitis (NANIPER) from control subjects. Nasal reactivity (nasal patency, mucus production, and sneezing) in 16 symptomatic nonsmoking patients with NANIPER and seven nonsmoking control subjects was measured with standardized CDA and histamine provocation series in a randomized crossover study. Intranasal CDA resulted in increased mucus production and nasal blockage in a dose-dependent manner in patients with NANIPER but not in control subjects. Sneezing did not occur. The reproducibility of CDA for patency and mucus production was good. Sensitivity for CDA was 87% compared with 100% for histamine. However, specificity was 71% for CDA and 0% for histamine. It is concluded that the new standardized intranasal CDA provocation method uses a recognizable natural nonspecific stimulus and seems to be more suitable than histamine for characterizing and assessing the presence and degree of nasal reactivity in NANIPER.
本研究的目的是比较冷干空气（CDA）和组胺在区分非过敏性非感染性常年性鼻炎（NANIPER）患者与对照受试者方面的差异。在一项随机交叉研究中，对16例有症状的非吸烟NANIPER患者和7例非吸烟对照受试者，采用标准化的CDA和组胺激发系列来测量鼻反应性（鼻通畅度、黏液分泌和打喷嚏情况）。鼻内给予CDA后，NANIPER患者的黏液分泌和鼻阻塞呈剂量依赖性增加，而对照受试者则无此现象。未出现打喷嚏情况。CDA在鼻通畅度和黏液分泌方面的可重复性良好。CDA的敏感性为87%，而组胺为100%。然而，CDA的特异性为71%，组胺的特异性为0%。得出的结论是，新的标准化鼻内CDA激发方法使用了一种可识别的自然非特异性刺激，并且似乎比组胺更适合于表征和评估NANIPER中鼻反应性的存在及程度。
