Thorn J, Rylander R
Department of Environmental Medicine, University of Gothenburg, Gothenburg, Sweden.
Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1798-803. doi: 10.1164/ajrccm.157.6.9706081.
A study was undertaken in a number of rowhouses, some of which had had previous problems related to dampness and water leakage. The aim of the study was to assess the relation between exposure to airborne (1--> 3)-beta-D-glucan, a cell-wall substance in molds, and airways inflammation. The study involved 75 houses with indoor (1--> 3)-beta-D-glucan levels ranging from 0 to 19 ng/m3. Of 170 invited tenants, 129 (76%) participated in the study. A questionnaire relating to symptoms was used, and measurements were made of lung function and airway responsiveness. Myeloperoxidase (MPO), eosinophilic cationic protein (ECP), and C-reactive protein (CRP) were measured in serum. Atopy was determined with the Phadiatop test. The major findings were a relation between exposure to (1--> 3)- beta-D-glucan and an increased prevalence of atopy, a slightly increased amount of MPO, and a decrease in FEV1 over the number of years lived in the house. The results suggests the hypothesis that exposure to (1--> 3)-beta-D-glucan or molds indoors could be associated with signs of a non-specific inflammation.
在一些排屋中进行了一项研究，其中一些排屋先前存在与潮湿和漏水相关的问题。该研究的目的是评估暴露于空气中的（1→3）-β-D-葡聚糖（一种霉菌中的细胞壁物质）与气道炎症之间的关系。该研究涉及75所房屋，室内（1→3）-β-D-葡聚糖水平在0至19 ng/m³之间。在170名受邀租户中，129名（76%）参与了研究。使用了一份与症状相关的问卷，并对肺功能和气道反应性进行了测量。在血清中测量了髓过氧化物酶（MPO）、嗜酸性阳离子蛋白（ECP）和C反应蛋白（CRP）。通过Phadiatop试验确定特应性。主要发现是暴露于（1→3）-β-D-葡聚糖与特应性患病率增加、MPO量略有增加以及在房屋居住年限中第一秒用力呼气容积（FEV1）下降之间存在关联。结果提示了这样一种假设，即室内暴露于（1→3）-β-D-葡聚糖或霉菌可能与非特异性炎症的迹象有关。
