McAllister-Sistilli C G, Caggiula A R, Knopf S, Rose C A, Miller A L, Donny E C
University of Pittsburgh, Department of Psychiatry, PA 15213, USA.
Psychoneuroendocrinology. 1998 Feb;23(2):175-87. doi: 10.1016/s0306-4530(97)00080-2.
Although considerable work has been done on the potential health effects of smoking, little is known about the contribution of nicotine to those effects. This paper presents an overview of the immune system, and a discussion of the existing literature on the effects of tobacco smoke and nicotine on immunity. Treatment with nicotine has been shown to influence all aspects of the immune system, including alterations in humoral and cellular immunity. In addition, preliminary data suggest that gender and genetic factors impact on the immunological effects of nicotine. Finally, the possible mechanisms that might mediate the effects of nicotine are discussed.
尽管在吸烟对健康的潜在影响方面已经开展了大量工作，但对于尼古丁在这些影响中所起的作用却知之甚少。本文概述了免疫系统，并讨论了关于烟草烟雾和尼古丁对免疫影响的现有文献。已证明尼古丁处理会影响免疫系统的各个方面，包括体液免疫和细胞免疫的改变。此外，初步数据表明性别和遗传因素会影响尼古丁的免疫效应。最后，讨论了可能介导尼古丁效应的潜在机制。
