Appel G B, Williams G S, Meltzer J I, Pirani C L
Ann Intern Med. 1976 Sep;85(3):310-7. doi: 10.7326/0003-4819-85-3-310.
We report here four cases of systemic lupus erythematosus associated with the nephrotic syndrome and renal vein thrombosis and review six familiar cases previously noted in the literature. Renal biopsy in each of our cases showed changes consistent with the membranous type of lupus nephropathy. We discuss the exclusive appearance of this pattern in relation to renal vein thrombosis in other forms of renal disease. The occurance of renal vein thrombosis in patients with systemic lupus erythematosus and the nephrotic syndrome supports the evidence that the thrombosis is a complication rather than a cause of the nephrotic syndrome. The presence of pleuritic pain in a patient with systemic lupus erythematosus and the nephrotic syndrome should alert the clinician to the possibility of renal vein thrombosis and pulmonary emboli. With appropriate diagnosis and anticoagulation therapy, our patients had a benign course during 7 to 48 months of follow-up.
我们在此报告4例系统性红斑狼疮合并肾病综合征及肾静脉血栓形成的病例，并回顾文献中先前记载的6例类似病例。我们每例患者的肾活检均显示出与膜性狼疮性肾炎相符的改变。我们讨论了这种模式在其他形式的肾脏疾病中与肾静脉血栓形成相关的独特表现。系统性红斑狼疮和肾病综合征患者发生肾静脉血栓形成支持了血栓形成是肾病综合征的并发症而非病因这一证据。系统性红斑狼疮和肾病综合征患者出现胸膜炎性疼痛应提醒临床医生注意肾静脉血栓形成和肺栓塞的可能性。经过适当的诊断和抗凝治疗，我们的患者在7至48个月的随访期间病情呈良性发展。
