Yamamoto T, Sakashita Y
Department of Anesthesiology, School of Medicine, Chiba University, Chiba 260-0856, Japan.
Brain Res. 1998 Jun 1;794(2):329-32. doi: 10.1016/s0006-8993(98)00306-0.
We investigated the effects of intrathecally administered N-type and P-type voltage-sensitive calcium channel (VSCC) blockers on the level of thermal hyperalgesia in two neuropathic pain models: the chronic constriction injury (CCI) model and the partial sciatic nerve injury (PSNI) model. N-type, but not P-type, VSCC blockers attenuated the level of thermal hyperalgesia induced by CCI in a dose-dependent manner. In the PSNI model, both N-type and P-type VSCC blockers had no effect on thermal hyperalgesia. This suggests that some types of neuropathic pain may be treatable with N-type VSCC blockers.
我们研究了鞘内注射N型和P型电压门控性钙通道（VSCC）阻滞剂对两种神经病理性疼痛模型——慢性压迫性损伤（CCI）模型和坐骨神经部分损伤（PSNI）模型——中热痛觉过敏水平的影响。N型而非P型VSCC阻滞剂以剂量依赖性方式减轻了CCI诱导的热痛觉过敏水平。在PSNI模型中，N型和P型VSCC阻滞剂对热痛觉过敏均无影响。这表明某些类型的神经病理性疼痛可能可用N型VSCC阻滞剂治疗。
