Rodrigues C, Desai S, Chinoy R
Department of Pathology, Tata Memorial Hospital, Bombay, India.
J Surg Oncol. 1998 Jun;68(2):100-3. doi: 10.1002/(sici)1096-9098(199806)68:2<100::aid-jso5>3.0.co;2-a.
Giant cell tumor of the tendon sheath (GCTTS) is a lesion of uncertain etiology. To better interpret pathogenesis and aid in the differentiation of GCTTS from other similar pathological processes we reviewed the literature and analyzed the available information.
We retrospectively studied clinicopathologic findings in 28 cases of GCTTS on the basis of anatomic location and histologic appearance of the lesion.
The GCTTS could be divided into those involving the common digits (20 cases) and larger joint group (8 cases) based on anatomic location. Grossly the digit tumors were small, multiple, surrounded by a thin fibrous capsule, and had a variegated appearance, while the large joint tumors were relatively large and covered by one or more layers of synovium. Microscopically both groups consisted of a mixture of round to polygonal histiocytes, foam cells, hemosiderin laden macrophages, and multinucleated giant cells. The giant cells seemed more abundant in the digit tumors, while the pseudoglandular spaces lined by synovial cells were more striking in the large joint group.
Local excision was the treatment of choice in the majority of the patients. Eight patients had local recurrence.
腱鞘巨细胞瘤（GCTTS）是一种病因不明的病变。为了更好地解释其发病机制并有助于将GCTTS与其他类似病理过程相鉴别，我们回顾了文献并分析了现有信息。
我们根据病变的解剖位置和组织学表现，对28例GCTTS的临床病理结果进行了回顾性研究。
根据解剖位置，GCTTS可分为累及常见手指（20例）和大关节组（8例）。大体上，手指肿瘤较小，多发，被薄纤维包膜包绕，外观呈杂色，而大关节肿瘤相对较大，被一层或多层滑膜覆盖。显微镜下，两组均由圆形至多边形组织细胞、泡沫细胞、含铁血黄素巨噬细胞和多核巨细胞混合组成。巨细胞在手指肿瘤中似乎更丰富，而滑膜细胞衬覆的假腺腔隙在大关节组中更明显。
大多数患者的治疗选择是局部切除。8例患者出现局部复发。
