Budman D R, Steinberg A D
Arch Intern Med. 1976 Sep;136(9):1003-7.
A retrospective analysis of 235 patients at the National Institutes of Health who met at least five criteria for systemic lupus erythematosus (SLE) indicated that 45% were hypertensive. Approximately two thirds of these hypertensive patients had creatinine clearances of more than 60 ml/min and nonnephrotic range proteinuria. Only 16% of normotensive patients had creatinine clearances of less than 60 ml/m9n. A subgroup of 36 patients with SLE and with biopsy-proved diffuse renal disease were studied. For these patients, the presence of hypertension could not be correlated with the degree of proteinuria or hematuria, with the level of serum complement, or with the presence of casts, focal necrosis, crescent formation, or interstitial inflammation. Hypertensive patients had a median age of 24.5 years; the majority had creatinine clearances of more than 60 ml/min. In SLE, hypertension is not necessarily associated with advanced renal disease, and high blood pressure may occur relatively early in the course of the disease.
对美国国立卫生研究院的235例至少符合五项系统性红斑狼疮（SLE）标准的患者进行的回顾性分析表明，45%的患者患有高血压。这些高血压患者中约三分之二的肌酐清除率超过60 ml/分钟，且蛋白尿处于非肾病范围。血压正常的患者中只有16%的肌酐清除率低于60 ml/分钟。对36例经活检证实患有弥漫性肾病的SLE患者亚组进行了研究。对于这些患者，高血压的存在与蛋白尿或血尿的程度、血清补体水平、或管型、局灶性坏死、新月体形成或间质性炎症的存在均无关联。高血压患者的中位年龄为24.5岁；大多数患者的肌酐清除率超过60 ml/分钟。在SLE中，高血压不一定与晚期肾病相关，高血压可能在疾病过程中相对较早出现。
