Zabawski E J, Cockerell C J
University of Texas Southwestern Medical Center, Dallas, USA.
J Am Acad Dermatol. 1998 Nov;39(5 Pt 1):741-5. doi: 10.1016/s0190-9622(98)70046-5.
Cidofovir is a potent nucleoside analog antiviral drug approved for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It is currently available only for intravenous infusion. Several small studies and case reports describe the successful use of cidofovir applied either topically or intralesionally in several virally induced cutaneous diseases.
Our purpose was to review the usefulness of topical and intralesional cidofovir for the treatment of viral infections caused by human papillomavirus, herpesviruses (including acyclovir-resistant strains), Kaposi's sarcoma-associated herpesvirus, and molluscum contagiosum.
We performed a review of recent literature.
Cidofovir is a potent topical intralesional antiviral agent with activity against several DNA viruses that cause cutaneous disease. No significant systemic side effects have been noted, although application site reactions are common and can occasionally be severe.
The effective use of topical and intralesional cidofovir for the treatment of diseases of the skin caused by DNA viruses has been demonstrated in a limited number of patients including those infected with HIV. Although larger studies will be necessary to determine the specific function that topical cidofovir will have in the treatment of cutaneous diseases caused by DNA viruses, the drug offers significant promise.
西多福韦是一种有效的核苷类似物抗病毒药物，已被批准用于治疗艾滋病患者的巨细胞病毒（CMV）视网膜炎。目前仅可用于静脉输注。几项小型研究和病例报告描述了西多福韦局部或病灶内应用于几种病毒引起的皮肤疾病取得成功。
我们的目的是综述局部和病灶内应用西多福韦治疗由人乳头瘤病毒、疱疹病毒（包括耐阿昔洛韦毒株）、卡波西肉瘤相关疱疹病毒和传染性软疣病毒引起的病毒感染的有效性。
我们对近期文献进行了综述。
西多福韦是一种有效的局部和病灶内抗病毒药物，对几种引起皮肤疾病的DNA病毒有活性。虽未观察到明显的全身副作用，但用药部位反应常见，偶尔可能较严重。
在包括HIV感染者在内的少数患者中已证明局部和病灶内应用西多福韦有效治疗由DNA病毒引起的皮肤疾病。尽管需要更大规模的研究来确定局部应用西多福韦在治疗由DNA病毒引起的皮肤疾病中的具体作用，但该药物前景广阔。
